Hello Wendy I am my wife's caregiver and also her computer operator. (not that she cant do it but Im more familiar with this thing and besides we do it together) Joyce's dr.(since her first diognosis 11 y/a) is a leading force with PD research and development in NYC. Abt four years ago he added vit C & E to her daily meds. The dosage of each was 3000 units/day She became to acidic, he reduced the C to 1500 the E remained the same. The results re PD are naturally hard to detect BUT HER SKIN IS LIKE BUTTER AND UPON ADVICE OF MY FRIENDS I HAVE BEGUN TO TAKE E IN ORDER TO KEEP UP WITH HER "SOCIALLY" for whats it's worth, CHUCK