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[log in to unmask]: I am replying via parkinsn since I read one message that requested public replys in order to make maximum use of information. If this is wasted space, let me know. I will send replys one-to-one. I was diagnosed as PD in Oct 93 with shakey handwriting and no/little arm swing when walking. I went on eldepryl 5mg 2x immediately. In Jan 94 I started on a blind pramipexole study. Dr. Kurth and I think I was on the placebo for 9 months, but we do not know for sure. In late Sept I started on the real thing 1.5 mg 3x. My handwriting is much better, but my arm swing is unimproved. On the plus side, I am better than I was in Oct 93 with no side effects. Low blood pressure is a possible side effect, but I have not experienced it. Dr. Kurth would like to increase dosage, but study prohibits it. I have accidently taken larger dosages with no noticible improvement. Perhaps a larger dosage over a longer period of time would help. Pramipexole is a dopamine agonist that mimics the effects of dopamine. I do not notice any effect if I forget a dosage, but that may be to my lack of severe symtoms. As best as I can tell there is no "on - off" effect. Dr. Kurth is very excited about the drug and I think I will stay on it when the 2 year free ride ends. Maybe the dosage will increase, but as of right now, I don't think there is much of benefit. I have noticed a rather marked increase in shakiness if I generate adrenalin through anger, excitement,fear etc. To offset this, Dr. Kurth prescribed propranolol 20mg as required. This seems to help also, especially if I can anticipate the requirement. That's all I can think of for right now. I feel fortunate to be on the pramipexole study and think it is helping. The eldepryl is also crucial in preventing further progression of the disease. Bye -- "Racing is life, everything before and after is just waiting."