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There is a discussion in Duvoisin's book (pp 125-127) about B6 and Sinemet. Briefly, B6 doesn't help much in PD. In the RDA dosage range, it is counteracted by the carbidopa component of Sinemet, so it doesn't hurt much either. However, therapeutic or megadose (10mg-20mg/day) of B6 can overwhelm the protection of carbidopa, and therefore should be avoided. If such dosage is warranted for reasons other than PD, the choice should be guided by a physician. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403 On Sat, 2 Sep 1995, H Spence wrote: > Someone wrote recently on the subject of Vit B6 and Parkinson, > that 'Earl Mindell's Vitamin Bible' is one of the best books on the > subject of vitamins. Remembering that I have that book, I dug it > up and found 'Parkinson and B6' and read the following: > > "Supplements for this vitamin should *not* be taken by anyone > under levodopa treatment for Parkinson's disease! (Ask your doctor > about Sinemet, a drug which can bypass this particular adverse vitamin > interaction.)" > > Don't know if it's just *me*, but I'm not sure I understand what he > means by Sinemet "bypassing this particular adverse vitamin > interaction." > If anyone reading this post does understand I'd love your > interpretation. > (It sounds to me like if you're on sinemet it's OK to take B6??) Also, > wondering, does Vit B6 'enhance' the benefits of sinemet or perhaps, > visa versa? Hoping this post makes sense to someone and look forward > to hearing from you if it does. :-) > > Ciao, > > Helen Spence >