PDR Generic Name Brand Name Original Use PD Use 2260 Albuterol Proventil Asthma Adjuvant (Experimental) helpful adjunct to levodopa 2617 Amantadine Symmetrel Antiviral Anticholinergic Helpful, but action mechanism unknown ---- Apomorphine ---- Emetic Neuroleptic Also an agonist, but may be nephrotoxic; available in Europe 1512 Benztropine Cogentin Anticholinergic Same Avoid phenothiazines and/or tricyclic antidepressants 1223 Biperiden Akimeton Anticholinergic Same Occasionally causes psychosis 2178 Bromocryptine Parlodel Migraine Agonist May cause hallucinations or nausea ---- Cabergoline ---- Hyperprolactinemia Agonist Experimental; long-lasting and well-tolerated 2149 Clozapine Clozaril Neuroleptic Same Effective against drug-induced psychosis, but risky ---- Dihydrexidine ---- ---- D1 agonist Experimental, animals only so far ---- Dihydroergocryptine ---- ---- D2 agonist Experimental, possibly neurotrophic ---- Domperidone ---- ---- Adjuvant Controls side effects of apomorphine, not yet available in US ---- Entacapone ---- COMT inhibitor Same Experimental ---- Ganglioside GM1 ---- Neurotrophic? Same Experimental; slight risk of Guillain-Barre syndrome ---- Lazebemide ---- MAO-B inhibitor Same Experimental, lasts longer than Deprenyl 959 Levodopa Sinemet, Madopar Dopamine source Same Current mainstay of PD drug therapy ---- Lisuride Dopergine Agonist Same Available in Europe ---- Nicergoline ---- Senility Adjuvant Together with levodopa, improved akinesia 2390 Paroxetine Paxil Antidepressant ---- Exacerbated symptoms of PD ---- Pramipexole ---- ---- D2 agonist Experimental; improved "off" periods 587 Pergolide Permax Agonist Same Occasionally causes hallucinations 2692 Primidone Mysoline Anticonvulsant Tremor Related to phenobarbital 2673 Propranolol Inderal Tachycardia Tremor Beta blocker, may lead to heart failure 764 Procyclidine Kemadrin Anticholinergic Same Occasionally causes psychosis ---- Ropinerole ---- Anxiolytic Antidepressant Experimental 2430 Selegiline Eldepryl, Deprenyl MAO-B inhibitor Same Neuroprotective effect still unconfirmed ---- Tocopherol Vitamin E Antioxidant Same Neuroprotective effect not found ---- Tolcapone ---- COMT inhibitor Same Experimental, promising adjuvant 1251 Trihexyphenidyl Artane, Tremin Antispasmodic Anticholinergic Related to atropine Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403