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Carol, my doc is dir. of PD research and development in NY. Whn he changed my meds, I did it in the hospital over one week. IM SHOCKED THAT THIS DR. DIDNT FOLLOW BASIC MEDICALLY PROVEN PROCDURES. Im off artane now (cant remember why) but im also on both senemets, parlodel and permax. I had pd for 11 years and hav managed to limit my distress to my legs and feet. good luck Joyce [log in to unmask]