PDR Generic Name Brand Name Original Use PD Use
2260 Albuterol Proventil Asthma Adjuvant
(Experimental) helpful adjunct to levodopa
2617 Amantadine Symmetrel Antiviral Anticholinergic
Helpful, but action mechanism unknown
---- Apomorphine ---- Emetic Neuroleptic
Also an agonist, but may be nephrotoxic; available in Europe
1512 Benztropine Cogentin Anticholinergic Same
Avoid phenothiazines and/or tricyclic antidepressants
1223 Biperiden Akimeton Anticholinergic Same
Occasionally causes psychosis
2178 Bromocryptine Parlodel Migraine Agonist
May cause hallucinations or nausea
---- Cabergoline ---- Hyperprolactinemia Agonist
Experimental; long-lasting and well-tolerated
2149 Clozapine Clozaril Neuroleptic Same
Effective against drug-induced psychosis, but risky
---- Dihydrexidine ---- ---- D1 agonist
Experimental, animals only so far
---- Dihydroergocryptine ---- ---- D2 agonist
Experimental, possibly neurotrophic
---- Domperidone ---- ---- Adjuvant
Controls side effects of apomorphine, not yet available in US
---- Entacapone ---- COMT inhibitor Same
Experimental
---- Ganglioside GM1 ---- Neurotrophic? Same
Experimental; slight risk of Guillain-Barre syndrome
---- Lazebemide ---- MAO-B inhibitor Same
Experimental, lasts longer than Deprenyl
959 Levodopa Sinemet, Madopar Dopamine source Same
Current mainstay of PD drug therapy
---- Lisuride Dopergine Agonist Same
Available in Europe
---- Nicergoline ---- Senility Adjuvant
Together with levodopa, improved akinesia
2390 Paroxetine Paxil Antidepressant ----
Exacerbated symptoms of PD
---- Pramipexole ---- ---- D2 agonist
Experimental; improved "off" periods
587 Pergolide Permax Agonist Same
Occasionally causes hallucinations
2692 Primidone Mysoline Anticonvulsant Tremor
Related to phenobarbital
2673 Propranolol Inderal Tachycardia Tremor
Beta blocker, may lead to heart failure
764 Procyclidine Kemadrin Anticholinergic Same
Occasionally causes psychosis
---- Ropinerole ---- Anxiolytic Antidepressant
Experimental
2430 Selegiline Eldepryl, Deprenyl MAO-B inhibitor Same
Neuroprotective effect still unconfirmed
---- Tocopherol Vitamin E Antioxidant Same
Neuroprotective effect not found
---- Tolcapone ---- COMT inhibitor Same
Experimental, promising adjuvant
1251 Trihexyphenidyl Artane, Tremin Antispasmodic Anticholinergic
Related to atropine
Cheers, Joe
J. R. Bruman (818) 789-3694
3527 Cody Road
Sherman Oaks CA 91403
