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Questions are being raised about the possibility of a new drug for Parkinson's disease becoming available in the next year or two. There is a new class of drugs undergoing development. One or two of them are likely to become available for general use in that time frame. These are known as COMT Inhibitors and have the generic names of entacapone and tolcapone. They are meant to be taken in conjunction with Sinemet or Madopar. The COMT inhibitors are meant to smooth out the beneficial effects attained from the administration of levodopa by providing better control of the drug's metabolism. I think many of us are anxious to find out if this new class of drugs will help control the symptoms of Parkinson's disease. Best regards, Joe Irr - Worldwide Product Manager - The Sinemet Brand ([log in to unmask])