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Lucy Hartley, You wrote: <About the third hour after taking each dosage of Sinemet, he starts to have a mild dyskinesia (feet and hands twitching--uncomfortably, but not painfully), which is accompanied by breathlessness--a frustrating, almost frightening sense of not being able to breathe. This twitching/breathlessness lasts an hour or so until his next dose of Sinemet kicks in. Since he doesn't take anything after 4:00 p.m., his nighttime breathlessness often lasts much longer than an hour. Is this a normal, expected side effect of the wearing off of medication, and/or a normal part of dyskinesia? Does anyone else experience the breathlessness? And has anyone found relief for this problem? I would appreciate hearing of your experiences. Thanks!> I do not have much dyskinesia, but it comes at peak dose - sort of too much neurotransmitter. I have what I believe is termed dystonia if I delay taking sufficient levodopa - this is often in the morning. It seems unusual to me that CR Sinemet was discontinued in favor of regular and that no levodopa is taken after 4 PM. If the hands and feet twitching is dystonic rather than dyskinesic and is using oxygen, the heart wants more oxygen from the lungs - but the muscles that work the lungs to breathe deeper or faster are not getting neurotransmitter signals sufficiently. I suggest a conference with a neurologist regarding evening medication - as well as advisability of taking half-tablets (or 10/100) every two hours approximately. Ron,59,PD-11 <[log in to unmask]> Ronald Vetter