Here's another abstract from Medline/Toxline possibly linking pesticides
(including the infamous DDT) and Parkinson's Disease.
Wendy Tebay
[log in to unmask]
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AU - FLEMING L
AU - MANN JB
AU - BEAN J
AU - BRIGGLE T
AU - SANCHEZ-RAMOS JR
TI - Parkinson's disease and brain levels of organochlorine
pesticides.
SI - BIOSIS/94/25827
SO - ANNALS OF NEUROLOGY; 36 (1). 1994. 100-103.
AB - BIOSIS COPYRIGHT: BIOL ABS. Epidemiological studies have
suggested an etiologic relationship between pesticide exposure
and Parkinson's disease (PD). Organochlorine pesticides were
assayed in postmortem brain samples from 20 PD, 7 Alzheimer's
disease (AD), and 14 nonneurological control cases. The three
groups were similar in age at death, sex, and demographic
variables. Only two of 16 pesticide residues screened were
detected. A long-lasting residue of DDT (pp-DDE) was found in the
majority of cases of PD and AD, as well as in all the control
cases; pp-DDT was significantly more likely to be found in AD
controls than the PD cases (Fisher's exact two-tailed, p = 0.04).
Dieldrin was detected in 6 of 20 PD brains, 1 of 7 AD, and in
none of 14 control samples. Despite the relatively small number
of brains assayed, the association between Dieldrin and the
diagnosis of PD was highly significant (P = 0.03). Dieldrin, a
lipid-soluble, long-lasting mitochondrial poison, should be
investigated as a potential etiological agent of Parkinsonism.
MH - BEHAVIOR
MH - HUMAN
MH - BIOCHEMISTRY
MH - NERVOUS SYSTEM/PHYSIOLOGY/METABOLISM
MH - NERVOUS SYSTEM DISEASES/*PATHOLOGY
MH - MENTAL DISORDERS/THERAPY/PATHOLOGY
MH - PSYCHOPATHOLOGY
MH - ENVIRONMENTAL POLLUTANTS/POISONING
MH - OCCUPATIONAL DISEASES
MH - HERBICIDES
MH - PEST CONTROL/METHODS
MH - PESTICIDES
MH - ARACHNIDA
MH - ENTOMOLOGY/ECONOMICS
MH - INSECTICIDES
MH - PEST CONTROL/METHODS
MH - PESTICIDES
MH - HOMINIDAE
RN - 53469-21-9; 27304-13-8; 12789-03-6; 12674-11-2; 12672-29-6;
11097-69-1; 11096-82-5; 3424-82-6; 1024-57-3; 789-02-6; 309-00-2;
115-32-2; 76-44-8; 72-56-0; 72-55-9; 72-20-8; 60-57-1; 58-89-9;
50-29-3
