Here's an abstract regarding pesticides and YOPD (young onset parkinson's
disease):
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6
AU - Butterfield PG
AU - Valanis BG
AU - Spencer PS
AU - Lindeman CA
AU - Nutt JG
TI - Environmental antecedents of young-onset Parkinson's disease.
SI - TOXBIB/94/224341
SO - Neurology; VOL 43, ISS 6, 1993, P1150-8
AB - We conducted an exploratory study of young-onset Parkinson's
disease (YOPD) to examine occupational and environmental factors
associated with disease risk. This case-control study included 63
YOPD patients (diagnosis on or before age 50); controls (n = 68)
were diagnosed with rheumatoid arthritis. Crude odds ratios (ORs)
were computed to identify exposure variables for logistic
regression analyses. After controlling for the variables of race,
educational level, sex, age, age at diagnosis, and family history
of Parkinson's disease (PD), PD was positively associated with
insecticide exposure (OR = 5.75, p < 0.001), past residency in a
fumigated house (OR = 5.25, p = 0.046), herbicide exposure (OR =
3.22, p = 0.033), rural residency at time of diagnosis (OR =
2.72, p = 0.027), and nuts and seed eating 10 years before
diagnosis (OR = 1.49, p = 0.021). PD was inversely associated
with cigarette smoking at 5 years (OR = 0.50, p = 0.027), 10
years (OR = 0.43, p = 0.012), and 15 years (OR = 0.37, p = 0.005)
before diagnosis, farm residency (OR = 0.38, p = 0.018), and
exposure to dimethyl sulfoxide (OR = 0.10, p < 0.001). These
findings are consistent with hypotheses linking PD to exposure to
pesticide agents.
MH - Adult
MH - Age Factors
MH - Case-Control Studies
MH - Dimethyl Sulfoxide/ADVERSE EFFECTS
MH - Environmental Exposure/*ADVERSE EFFECTS
MH - Family
MH - Female
MH - Human
MH - Male
MH - Middle Age
MH - Nuts/*ADVERSE EFFECTS
MH - Odds Ratio
MH - Parkinson Disease/*ETIOLOGY
MH - Pesticides/*ADVERSE EFFECTS
MH - Questionnaires
MH - Regression Analysis
MH - Rural Health
MH - Smoking/ADVERSE EFFECTS
MH - Support, U.S. Gov't, P.H.S.
RN - 0 (Pesticides)
RN - 67-68-5 (Dimethyl Sulfoxide)
