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Your father may not benefit from increased "E". I am the same age and was
diagnosed one year ago. The main reason I went to the Dr. was that my legs
jumped or twitched, especially at night. I had to get up and walk or do
something active. The neurologist said that the combinations of other
symptoms-such as difficulty writing, brushing my teeth, speech problems, and
others, indicated PD.  Regular Sinemet improved the symptoms confirming his
diagnosis. Of course I was skeptical and had to get a 2nd, but the series of
tests also confirmed the PD.  After I took Sinemet CR 25/100 for a while it
seemed that my symptoms were even worse as the med wore off and before the
next CR helped.  My conclusion was that the med was perhaps making me worse
or increasing the progression of PD, but I haven't heard much about that and
 have not had the courage to take a med holiday.
 
A few months ago because the legs and occasionally the arms jumped the neuro
put me on Permax (dopamine agonist).  After considerable difficulty
increasing the dosage (dizziness and low BP) I am now on 3 Permax .25mg.  I
do not now have jumpy legs or arms and my Sinemet level is still the same.  I
will try reducing the Sinement CR some as soon as I fully recover from recent
surgery.
 
As you read the list you will find that there are few PD's with the exact
symptoms or meds or methods of coping. To me it is absolutely fascinating to
read the discussion.  I note that many posters are quite cautious about their
recommendations - others are excitedly advocates; which is fine with me.
 Parkinsonians, Caregivers, Researchers, Relatives and anyone else interested
in PD hold widely different views.  Sometimes I wish PD were more like my
coronary artery disease.  I can see it and know what to do about it.  The
most interesting aspect of the disease is the general agreement on the role
of dopamine.  Although I have tried to learn and understand the explanation
regarding brain cells, etc., I couldn't give a good description of how it all
works.  In fact I am still looking for a really good detailed definition and
explanation.
 
WELCOME TO THE PARKIE LIST,    Fred