Your father may not benefit from increased "E". I am the same age and was diagnosed one year ago. The main reason I went to the Dr. was that my legs jumped or twitched, especially at night. I had to get up and walk or do something active. The neurologist said that the combinations of other symptoms-such as difficulty writing, brushing my teeth, speech problems, and others, indicated PD. Regular Sinemet improved the symptoms confirming his diagnosis. Of course I was skeptical and had to get a 2nd, but the series of tests also confirmed the PD. After I took Sinemet CR 25/100 for a while it seemed that my symptoms were even worse as the med wore off and before the next CR helped. My conclusion was that the med was perhaps making me worse or increasing the progression of PD, but I haven't heard much about that and have not had the courage to take a med holiday. A few months ago because the legs and occasionally the arms jumped the neuro put me on Permax (dopamine agonist). After considerable difficulty increasing the dosage (dizziness and low BP) I am now on 3 Permax .25mg. I do not now have jumpy legs or arms and my Sinemet level is still the same. I will try reducing the Sinement CR some as soon as I fully recover from recent surgery. As you read the list you will find that there are few PD's with the exact symptoms or meds or methods of coping. To me it is absolutely fascinating to read the discussion. I note that many posters are quite cautious about their recommendations - others are excitedly advocates; which is fine with me. Parkinsonians, Caregivers, Researchers, Relatives and anyone else interested in PD hold widely different views. Sometimes I wish PD were more like my coronary artery disease. I can see it and know what to do about it. The most interesting aspect of the disease is the general agreement on the role of dopamine. Although I have tried to learn and understand the explanation regarding brain cells, etc., I couldn't give a good description of how it all works. In fact I am still looking for a really good detailed definition and explanation. WELCOME TO THE PARKIE LIST, Fred