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Hi, Pam here. I have to tell you it matters a great deal to let all the other ladies out there who are on their monthly periods, that its effects are really manifested at this time. For example, the drugs do not have near the potency or effect as it would normally. I find the ware off period is sooner. Awhile back I filled out a question sheet at The Toronto Western Hospital in Toronto under the direction of Anthony Lang, and it asked everything to do about the Menstrual Cycle in women. It has to play a big part in our lives and a lot more research should be done on this particular topic. It makes only sense that when your blood and hormones are fluctuating as much as ours are at this time that the Parkinson's is going to be effected. Thank you.\\ Pam Deslongchamps.\ 43,13./