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For about the past year I've been taking Sinemet 25/100 tid, without any dramatic effect, and with my insatiable curiosity I decided to experiment (this is ok with my Kaiser neurologist, who sees me only about twice a year). BTW, I'm 73, diagnosed about 2 yr with mild symptoms, also taking Mysoline 25 mg (half tablet) bid for tremor. Anyhow I tried skipping the noon Sinemet, cutting the daily dose by a third, and I feel better! Chronic weakness and lack of endurance (the most troublesome PD symptom) much improved, the extreme pain on knee extension (going up or down stairs, arising from chair) disappeared, and mirabile dictu, extreme oiliness of neck and scalp went away! Note well, I didn't stop Sinemet entirely, just cut the dose. And I have only done this for a few days so far, have no idea if I can continue or if the effects will persist, but they are so striking that I thought it worthwhile to put out a message. What does it all mean? Would like to see comment, especially from you professionals out there. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403