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Current Science Reviews by Joe Bruman October 1995 (part 2) Quattrone, A. et al: Ann Neur 1995;38:389-395: Response to levodopa in PD has both a short-term and a long-term component. The short-duration response (SDR) lasts a few hours, the long-duration response (LDR) may take several days of dosage to appear and equally long to decline after dosage is interrupted. Authors tested motor function in 25 patients under varying interval regimens and found that the optimum strategy (most sparing of levodopa) depends on the patient. Freeman, T. et al: Ann Neur 1995;38:379-388: Authors report good tolerance and results in four bilateral fetal nigral transplants. They used cyclosporine to suppress immunity and PET fluorodopa scans to confirm the clinical findings. Markopoulou, K. et al: Ann Neur 1995;38:373-378: Authors report a family kindred of 98 people in 6 generations, of whom 16 people developed autosomal-dominant, levodopa-responsive parkinsonism. "Life is just a bowl of cherries." Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403