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Hello Lisa, my b.p. is usually low so i cant speak abt that. I have had no ill effects from the C. However, it does make u "go" a little more often. abt the E it has been documented throughout the pd world and in various news letters that E has been found to slow the progression of pd. Ive been on it for many years. Aside from slowing pd progression, E is known and in my case my husband confirms that my skin is like silk. Dont laugh, but if you look up E in the books you will see that one (not too bad) effect is an increase in your libido. (Chuck started taking E some time ago) So much for those surveys of some months ago. HA HA. Have fun joyce