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All right, I guess I'm gonna have to jump in to this NADH conversation. I was roused by David Devor's charges that sounded a lot like "snake oil". Well,let me say this, I agree with you David, up to a point. Some of you may recall my one person, unblind, non-placebo study of NADH a couple of months ago, which I posted updates on to this list. I may be crazy, but I like to think I'm not stupid. Fact is, I embark on new-fangled treatment alternatives on a regular basis, BUT not without extensive research first. The thing that bothered me the most about NADH was that there appeared to be lots of supporting data at first, but it all turned out to be the same study by Dr. Birkmayer, which was then highly touted by Dr. Atkins, who was the marketing genius. And at first, Dr Atkins and the Menuco Corp appeared to be the only source. Since, other purveyors of snake oil have appeared, and the cost is starting to drop. BTW, recent studies have shown even snake oil to have therapeutic benefit. But, like any good young onset parky, I weighed the evidence and embarked on the journey. I was scared to death, because I didn't have data that I was confident in, but what I did have at least didn't indicate any serious side-effects. Heck, I'll use a good quality placebo if it works and the side-effects are tolerable!! The results: I discovered immediately that the combination of NADH and sinemet put me over the edge, so I reduced my sinemet. To me that alone is a significant benefit. I am not sure if NADH alone would provide adequate symptomatic treatment, but it seemed to act like a booster. And not nearly as boring as parlodel or permax. In fact, down right exhilarating at times. (Some of you may recall my post re: my enhanced libido...I think orders surged that week) Unfortunately, I also experienced the one side effect that was cautioned...insomnia. I'm no great sleeper anyway, but NADH redefined insomnia for me. I understand that not everyone is affected this way, in fact of the three live humans that I know have used NADH, I'm the only one that suffers that. But the sleep deprivation took too great a toll on me, interfered with my ability to work, which is getting more difficult anyway. So, reluctantly, I had to stop using it. In conclusion: I don't think NADH is for everyone, but it probably has benefit for some. I don't think it will ever be the cure-all that Dr. Atkins has been hoping it would be, but it ain't exactly a pig in a poke either. That concludes the official results of my study, now I'm gonna visit David's web site and see what's happening there.... Kathie Tollifson ([log in to unmask])