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Regarding discontinuing eldepryl, my physcian has me on parnate, a MAO A and MAO B blocker. He cites the analysis of spinal fluid that followed up on the statistics of the datatop study. It showed that Dopamine metabolism was not being inhibited by Eldepryl. His reasoning is that perhaps with the inhibition of MAO A, the brain shunts the dopamine metabolism to MAO B. Instead, inhibiting both ought to do the trick. There have not yet been clinical trials to see if parnate is any more effective in decreasing the metabolism of dopamine. Parnate is not very expensive, but does require some dietary restrictions: no cheese, yogurt, red wine, aged meats, i.e., anything with significant levels of the amino acid tyramine. Parnate cannot be taken alongside many other PD drugs. Hope this gives grist to the mill. David hopkins (43,2)