Due largely to the comments I read in the group, I talked things over with my doctor and decided to start taking Permax. I am now taking three x 5 microgram tabs three times daily = 45 micrograms. At an earlier level of dosage, I found that the twitches I used to have in the evening have just about disappeared and I am almost still when lying in bed (for which my wife, Margaret, is very grateful). From this, it follows that the Permax must be doing some good. My problem now is that the only people with any knowledge of permax are you guys out there and my neuro - neither my pharmacist nor doctor have any experience of it. I spoke to my neuro's nurse on the 'phone and, through her, he told me that I would know when to reduce my Sinemet intake because I would start to notice side-effects. In the meantime, would I please make arrangements, through my doctor, to visit him for an 'updating' appointment. (This is the UK National Health Service, remember) Unfortunately, it might take me some time to get to see my neuro and so I appeal to you.... What are the 'side effects' that will indicate it is time to reduce the sinemet and at what level of Permax intake did you start to notice them. Alll help will be much appreciated. Thanks. Ron Herstell [log in to unmask]