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Howdy all from the sunny Southwest! Winter has finally arrived, we can tell because it's finally dropped below 90*. I have run the race with NADH, and finally have some good news to report! I feel GREAT!!! I have hung in there for three weeks now, through a sleep deprivation marathon that I thought would never end. I seem to be the only one that gets that yummy side-effect. The first real plus for me was about 1 1/2 weeks into it, I realized that I wasn't suffering with Restless Legs as I wandered the house all night. Next I realized that my dyskenesia had diminished, and that I was not doing the "bobbing" around in the off to on state. Keep in mind that all this time I have been gradually reducing my other parky meds. I have eliminated 100 - 150 mgs of sinemet per day, knocked off 5 mg of Eldypryl, and dropped 1-2 Parlodel per day (I was taking 4). All this on one 2.5 mg of NADH! I have stayed at that dose for probably 2 weeks to adjust to it, and to alter other meds accordingly. The best news of all is that over the last 2-3 days I have noticed a real change in how I feel. That "edge" seems to have diminished, and I have slept SEVEN hours the last 2 nights! It has been years since I have gotten that much sleep. I feel almost normal, well rested, no dyskenesia, legs relaxed and not twitching and jumping. I think that I have finally dropped below the toxic level of sinemet in my body. Whew! I don't know where to go from here, so I think I'll just stay here for a while! I am so glad to finally have a good report....I hoped that NADH had something to offer, and at least for now it does. Jeffrey, if you are having problems with dyskenesia, gradually reduce your sinemet. The combo of NADH and sinemet is a powerful team, but go at it slowly or you will find yourself in a big OFF. I even break off the end of my CR's and spit out part, this does cause them to metabolize faster, so your meds cycle may be shorter. I have been switching to regular 25/100's, since a broken CR is no longer time-release anyway. That's all folks.... Kathie Tollifson 45,7 [log in to unmask]