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Dar, I can't offer any help or insight into your problem, but I have the same experience. About 20 minutes or half an hour after taking my medication, I experience increased stiffness in my neck and shoulders. This lasts about half an hour. The stiffness is _not_ an end-of-dose phenomenon; it is a beginning of dose phenomenon, just as you described. My neurologist was reluctant to believe this, but I have charted the stiffness and the occurrences are predictable. The increased stiffness does not occur when I delay taking the next dose by an hour or more; it does occur when after I take the new dose. Margot >I am inquiring as to what can be done related to stiffnes and l>imited movement just after taking medicaiton. I am finding that >for about 45 minutes to an hour after taking my medication that my >neck shoulders and arms become more stiff and it is difficult to >move.