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Hi Dar, I take 10 25/100 regulars sinemets/day Dr. equated these 10 X 100 to equal 1000cc Since I will take a drink every hour until my last at 8PM we divided the total 1000cc into the number of drinks to determine the amount of each drink. Since my first normal dosage is at 6AM, the evening before Chuck measures out 1000 cc into an empty litre soda bottle. He fills it with 3/4 OJ 1/4 water (only because the full strength OJ is too acidic for me.) You can use Tang, Gaterade or whatever your taste permits. Thats it Dar. Knock on wood or anything else but today is exactly two weeks and I have had only one incident of toe/foot cramping. Im sure that was due to a stressfull incident at that moment. The stiffness and the freezing continues..albeit with less duration..but its definitely still a problem. BUT NO MUSCLE CRAMPING WOW!! Good luck Joyce DISCLAIMER: THIS WORKS FOR ME. I AM NOT SUGGESTING THAT IT WILL WORK FOR ANYONE ELSE...IN FACT IT MAY WORSEN YOUR SYMPTOMS. ALTHOUGH YOU WOULD STILL BE TAKING THE SAME TOTAL AMOUNT OF SINEMET, THE PROCESS MAY NOT BE FOR IN YOUR INTEREST. PLEASE SPEAK WITH YOUR NEURO. JT