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Alice, a long time parkinsons patient, has been on similar dosage,using ascorbic acid instead of OJ, etc., for more than a year. it helped enormously in smoothing out highs and lows; it was originally recommended by the movement disorder center at the university of southern florida; understand liquid sinemet is soon to be marketed. we too, use glass soda water bottles, 12 a day. She takes a kick-start of one, 25/100 senemet and 30 cc on arising and then 60 cc each hour during the day. talk to your doctor before trying this. [log in to unmask]