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Greetings: My mother asked me to pass on this question to the discussion group. I believe her main interest is in hearing what success people have had in adjusting the kinds of medication my father is taking, and how to deal with the disruption to sleep that frequent medication requires. Any response, either to me directly or the discussion group, would be appreciated. (Question follows:) John is 52 years old and has had symptoms of PD for 8 years and on medication in increasing amounts for almost as long. He has a pretty good mobility for a few hours in the day but with some bad 'drops'. He is having to lie down and rest for much of the day. Without this dose of medication he would have bad tremors and very hard muscles and cramping muscles. He has some memory and confusion problems. The medication at this level aggravates that problem. We have help in for three nights to give the pills but I find the other four nights disruptive to my sleep. He takes the following medication: Type of medication -- Total daily amount Pergolide 0.25 mg -- 2.75 mg per day CR Sinemet 200/50 mg -- 2200 mg per day Sinemet 100/25 mg in liquid -- 210 mg per day Ativan 1 mg -- 2 mg per day He takes one Pergolide and one CR every two hours from 8am to 10pm and the same every two and a half hours at night. The liquid and Ativan supplement the situation. Any comments on what people have done at this point in terms of: 1) coping with side effects such as hallucinations, and 2) the inconvenience of the frequent nightly doses; and 3) has anyone taken larger doses of these medications successfully? Darlene.