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There is a discussion of vitamins in Duvoisin's book (old reliable): Briefly, vitamin B6 (pyridoxine) converts levodopa to dopamine faster than you want, i.e., before it gets in the brain where it is needed. The carbidopa component of Sinemet counteracts that effect, however, so you can take B6 with Sinemet *in reasonable quantity*. As for B12, except for general use as a supposed tonic, it has no effect on PD. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403 On Tue, 7 Nov 1995, Douglas K. Turner wrote: > I have read that Vitamin B6 interfers with the uptake of L-dopa even in > tiny amounts. Yet list members have been recomeneding a Vitamin B > supplement for PD. I used to take a high dose multi-vitamin supplement but > stopped when I read about B6. > > Is a high dose B Comlex good for PDers or not? If it is good, does anyone > know how it works? > > Confused, > Diane > -- > Diane Turner > [log in to unmask] >