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Dar, I read ur message and I can offer the following My neuro has explained my symptoms as OFF DYSTONIC meaning that I go OFF during the lower downswing of my med cycle. I come up again on the upswing time after taking the next dose. It was quite difficult to know that every two hours I was going OFF. He changed my sinemet from pills to liquid. Without exact details because we are all on different amounts and times each night I dilute the next days total sinemet into OJ. Each hour during the day I take a drink. Its been 13 days now and for a total period of two weeks, I must say that It has been a wonderful change. Speak with him and maybe this will help. good luck joyce joyce44