>The worst part of the "on-off" which I'm sure you are familiar with is the >feeling of total exhaustion and shortness of breath. Cathy, Joyce, John Cottingham, and Others: I posted a question to the list some time ago about breathlessness during in-coming and out-going dyskinesias. My Dad (76, diagnosed 8 years) suffers severe breathlessness during dyskinesias. Some members on the list responded that he seemed to be severely under-medicated for his age. His dosages are: 8:00 a.m. 25/100 Sinemet 9:00 a.m. 1 5-mg. Eldepryl 12:00 Noon 25/100 Sinemet 4:00 p.m. 25/100 Sinemet He had been on Sinemet-CR previous to these dosages, but I think he had hit the toxic levels because in the last year he had begun to suffer long-lasting, totally debilitating dyskinesias--which included the same severe breathlessness he experiences now. His neurologist took him off CR completely and put him on the much lower dosages, hoping to alleviate the terrible dyskinesias. The dyskinesias are much milder now, but the breathlessness continues and is just as severe. It doesn't seem to be related to anxiety or panic attacks. It's as if his chest muscles "freeze" just like his legs freeze when walking. His neurologist doesn't think the breathlessness is caused by under-medication. He really doesn't seem to have any answers for this particular problem, unless it IS freezing and rigidity of chest muscles causing the breathlessness. Any similar experiences out there? Comments, feedback, suggestions, prescriptions for *relief*? Thanks. Lucy Hartley [log in to unmask]