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I see everyone discussing the potential benefits of various vitamins and cofactors. I personally think there is general benefit to many of them. As I mentioned in an earlier post, CoQ would probably only be of benefit if one has a deficiency of it in the first place or a defect in the pathway that uses it. I would caution that when you buy vitamins and cofactors that you buy the most pure preparation you can find. No one ever mentions the impurities in these preps. No one, let alone people with PD, need extraneous chemicals potentially interferring with brain function. So really grill your health food vendors before you buy. CoQ, by the way, is available over the counter in any drug store. It's not cheap. I personally think it is good to take antioxidants (Vit C, E, etc.) to prevent free radical damage whether you have PD or not. It is becoming better understood that free radicals damage DNA (particularly the mitochondrial DNA...yes, if you didn't know it, there is DNA in the mitochondrion as well as in the nucleus of every living cell and it's an important player in the production of energy [ATP]). By the way, I'm not just a scientist who's interested in PD. I have 2 family members with the disease, one of which was my mom who braved it out for 27 yrs, back before L-DOPA was available and in the time when cryosurgery for the brain was the only effective treatment. Treatment has come a long way in 20 years but as you know it isn't all rosy. I am curious to find references on what you all are calling "NADH" as a supplement. I will also search Medline for references here at our Med School and share what I find. Delana Vaughan