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My update. I started taking NADH 1 x 2.5mg daily three weeks ago and have found the following: NO DIFFERENCE no loss or gain of sleep. Possible ??? increase in memory. NO DIFFERENCE in my PD symptoms. (I must add that at the same time I started to Liquidify Sinemet) That has eased my symptoms greatly So, to be fair to NADH at the end of this packet I will be increasing to 2 X daily now that the L>S> has had a chance to settle in. Its interesting to know how others are doing with this. Joyce