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In a message dated 95-11-19 03:09:37 EST, you write: > >In my case, i was diagnosed at age 25, started Sinemet, and my dyskinesia >began last year; i'm now 28, so dyskinesia began two years after i began >Sinemet, and about 4 years from the time (in hindsight) i noticed the first >symptom In my first message on dyskinesia I should have emphasized that debilitating dyskinesia didn't occur until many years later. at present time dyskinesia can becomes so severe that it is difficult for my wife to even eat; go out in public, etc. we moderated the dyskinesia significantly last year by going to hourly doses of liquid sinemet, which has been discussed on this list previously, and that smoothed out the severe fluctuations caused by the kickin of sinemet. Five weeks ago she had (we hope) fetal tissue implant surgery at Denver as part of the double-blind study involving 40 Pakinsons patients, being financed by nih. we are hoping that if she got the real thing she willbe able to cut back on the sinemet and thus greatly reduce the dyskinesia.