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I'd be interested in suggestions for adjusting to sinemet cr. I spent a miserable weekend trying to do just that and finally had to give it up. One pill (25/100) overmedicated me and I had manic episodes and lots of dyskinesia. Cutting the pill negated the cr effect and was not as effective as standard sinemet because it took a bit longer to kick in. The reason I tried the cr is that I need to take medication every 60 to 75 minutes, so my life revolves around this schedule. If I miss a dose by a few minutes or eat too much, I can be off for hours. Response is becoming increasingly erratic. I've taken sinemet for ten years. Any suggestions?