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To pschark--are you aware that Sinemet CR also comes in a 1/2 dose tablet: 25/100 instead of 50/200 ? That AVOIDS THE NEED TO BREAK THE TABLET. Peter has used them successfully when he missed a dose at the properqtime and w asn't ready for the next full dose. Give it a try? Good luck. And remember all the talk on this list about melatonin (not to mention the cover story in Newsweek) which re-sets the body clock and help with sleep? Maybe that would help you also. Camilla Flintermann(C) Peter(76-6) Oxford,OH