TO P. Schark I've had Parkinsons for about 12 years and use Sinemet CR. I have had difficulty in controling the level of the drug reaching the brain but have got fairly good at staying mobile. Try the following: 1. Keep off protein during the day. Try to keep to small but frequent amounts of carbohydrate. If you can stay a bit hungry it makes sure that food carries the tablet into the intestine within about 45 minutes. If it does seem to be stuck, a drink of coke or any sweet fizzy drink often helps. 2. I take half a tablet every two and a half hours. I decrease the time between tablets if I am doing something very energtic. Make sure you wash the tablet down from the throat. I use a pill box with a timer from Radio Shack to make sure I don't forget. 3. Keep active. I find that a daily walk or visit to a gym is a great help. 4. I carry Madopar dispersable with me and take a top-up if I feel an off period coming on. 5. When I need to l keep mobile, when walking in the country for example, I carry a syringe of apomorphine with me and take a Domperidome tablet to avoid sickness. I don't often use it as the Apomorphine side effects are a bit unpleasant but at least its a guaranteed way of keeping mobile and out of danger. Hope you find some of this useful - it works for me most of the time. Nigel Cockle.