Thanks to all who replied and shared your experiences with CR. I checked my bottle, and it does say 25/100 CR. It is half of that I was taking. My neurologist thinks that wasn't enough, and suggests I need 3/4 or alternating 1 and 1/2. He thinks the day and a half trial wasn't sufficient for me to know anything, especially since I was experimenting with the dosage during that time. Unfortunately, when I called his answering service Sunday morning, the neurologist on call was not a Parkinson's doctor and advised me to stop taking the CR. I'd like to find a convenient time to withdraw from the world to try this again, but can't imagine when that will be. My neurologist had his students research melatonin, since I was interested in trying it for my insomnia, and he claims it's contra-indicated for PD because it makes the symptoms worse. No one seems to have experienced that problem, however, and I'd sure like to try something. He's also one of the researchers on the DATATOP study and isn't at all convinced eldepryl slows the diseas's progression for those taking sinemet. This contradicts most of what I read about it, though. He had me stop taking it last year because it gave me insomnia and he doesn't want me to take sleep medication. I agree with his philosophy of keeping meds to a minimum, but some of this is necessary and I find myself wishing he weren't quite so conservative. Since your response was so helpful, I'd like to bring up another problem. I'm a high school teacher and have been working for ten years after diagnosis. As you probably know, teaching is no picnic these days for healthy people, and I'm experiencing enough problems that tell me it's time to retire. My doctor disagrees, however, and feels I can work much longer. Therefore, he won't help me apply for a disability retirement and I'm not eligible for regular retirement for five more years. Like all of us, I'm concerned about the future, economically as well as medically, and feel I can't afford to sacrifice my retirement benefits by pulling out early. What to do??? Pat Schark ([log in to unmask])