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Waytogobill: This Rx is not official therapy...I got it from my dr. to try to overcome my OFF dystonia. Using 25/100 Sinemet equate the total amount of the LAST NUMBER (100) into 100cc of OJ. I.E. I take 10 25/100 mixed together with 1000cc OJ PLUS 1000cc or one teaspoon of powered vit C Then divide the number of hours from your first dose in the AM till your last dose in the PM into the total amount of OJ and that becomes your dosage per hour. To avoid coming down into OFF I first tried taking a drink every two hours. Reduced it to every hour and find that works good enough to smooth out my day. Occassionally though, I divide the hour drink in half and take a drink every 1/2 hour. As long as you take the total amount over the total hours, you may find a much smoother ON/OFF day. Remember, this is my docs recommendation to me It may not be for you so please ask before you try it. Joyce