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Joyce, I had difficulty following your recommendations and calculations for making your special brand of Liquid Sinemet. You wrote the following: >Using 25/100 Sinemet equate the total amount of the LAST NUMBER (100) into 100cc of OJ. I.E. I take 10 25/100 mixed together with 1000cc OJ PLUS 1000cc or one teaspoon of powered vit C One teaspoon of powered vitamin C is equal to 4 grams = 4000 mg of vitamin C. If you consider that you are putting this in OJ, it has a lot of vitamin C. That is OK. The usual formula is 1/2 level teaspoon of Vitamin C in 1 liter of water. This is 2000 mg of Vitamin C. You then define how to calculate the size of a dose. You state the following: >Then divide the number of hours from your first dose in the AM till your last dose in the PM into the total amount of OJ and that becomes your dosage per hour. To avoid coming down into OFF I first tried taking a drink every two hours. Reduced it to every hour and find that works good enough to smooth out my day. Occasionally though, I divide the hour drink in half and take a drink every 1/2 hour. If I assume a pill every three hours starting at 7 am until 10 pm. then the total number of pills taken is one at 7, 10 , 1, 4, 7, 10 or 6 pills which is equal to 600 mg of levodopa over a 15 hour period (7AM - 10PM). 600 / 15 = 40 cc per hour. If you take a 40 cc drink starting at 7AM, you will be out of LS at 9PM. All this is confusing. Could you be a little more specific? Why do you take more LS than what the equivalent pills would provide? Regards, Alan Bonander Age 55, Diag 11 yrs, liquid meds, pallidotomy [log in to unmask]