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To Joyce Tames People who start liquid Sinemet almost always will find they either need more medications or less medications. The argument goes like this: If current PD makes ON with dyskinesia so painful, the patient will most likely under medicate to avoid the painful dyskinesia. When LS removes peak dose dyskinesia, the level of medications can be increased without fear of the dyskinesia. This is the most common case. If OFF time is so painful that the patient would rather have dyskinesia than endure a "drug resistant off period" the patient is most likely over medicated. Switching to LS allows the patient to lower medication levels without fear of landing in a "drug resistant OFF" problem and at the same time not experience dyskinesia for over medication. So it can go either way. Hopefully, as you have experienced, the patient is more predictable and properly medicated. Regards, Alan Bonander Age 55, Diag 11 yrs, liquid meds, pallidotomy [log in to unmask]