My wife has PD for 20 years and now she is hallucinating and confused very badly. I heard about ZOFRAN, that is being research for the promlem. Can anyone share about this drug for this purpose. thanks. Abraham Freund [log in to unmask] On Sun, 3 Dec 1995, J.R. Bruman wrote: > I agree with your remarks about levodopa possibly enhancing undesirable > free radical production in the brain. Somewhat more ominous, however, is > the possibility that dopamine itself can be harmful, in excess. The > current therapy which delivers dopamine to deficient areas in the > substantia nigra seems crude at best and difficult to regulate, and the > research on apoptosis seems to indicate that excess dopamine is one of > the stimuli that cause dopaminergic neurons to shut down (atrophy? or > die?). If true, this hypothesis supports the notion that levodopa therapy, > while known to be effective, should be approached cautiously and frugally. > For most of us this presents a tough choice, impossible to confirm, and > we can only hope for the day when those neurons can be restored and > preserved. > Cheers, Joe > > > J. R. Bruman (818) 789-3694 > 3527 Cody Road > Sherman Oaks CA 91403 >