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I've been taking 100 mg of Amantadine once a day in the AM and it helps me a lot. My neuro told me to double that to twice a day and I got a severe case of constipation! I stopped taking Amantadene all together, and my digestive system came back to normal, but of course my PD symptoms got worse. I'm back to 1 Amantadine per day and that seems to be a good compromise so far. Does anyone else take Amantidine and suffer from constipation? What do you suggest to help? I hate taking medication to solve another medication's side effects. :-( Bruce McCallum, 60, diagnosed 5 yrs ago