A (At) 0:21 13/12/95 -0500, Delana Vaughan ecrivait (wrote): >I have just read a Leter to the Editor in the >J.Neurol.Neurosurg.Psychiatr.1995;59:555-565 by D.E. Bateman. The title is "A >simple model to explain the motor fluctuation seen in Parkinson's Disease." >This letter ... >Thanks. I think you'll find this a challenge worth pursuing. > >Delana Vaughan About Dyskinesia. ---------------- - I intend to get and read Bateman's letter to the Editor. - My PD, supposed to have begun in 1981, was discovered in 1983 and cured from that moment with l-DOPA (Sinemet) with some episodic attempts of other chemicals (bromocriptine, lisuride,...). After several years of l-DOPA therapy (I write this note down as I remenber but I'll send more precise details later on), I suffered from daily dyskinesia (each afternnon) which proved difficult to master. So I underwent some sets of observations and measurements in order to understand what was going on. Surprisingly, I noticed a "yo-yo effect" i.e. alternate transitions of short periods from stiffness to dyskinesia. From these observations I was led to the conclusion that I was subject of a undamped relaxation effect -i.e. a process including feedback controll- which can, on severe circonstances lead to sudden blocking effects. Various models can lead to relaxation. For example, intersynaptic recapture of dopamine could be invoked as well as l-DOPA -> dopamine inhibition by recycling of dopamine metabolites. - On the basis of the undamped hypothesis, I succeeded to master a dyskinesic situation by minute up/down variations (from 125mg up to 325mg per week [sic!]). But it took me months to achieved this. - As far as the hereupon described case applies, dyskinesia shall be avoided because the "yo-yo" effect may lead to a misunderstanding of the situation (overdose) as off-state may appears more noticeable than on-state. Becare of an overdose spiral! - Nowadays, after more than 12 years of l-DOPA therapy with adjustments from time to time, dyskinesia is no more a problem ("I hope it'll last" as said Laetitia Bonaparte, mother of Napoleon I, in quite different circumstances). Looking forward for comments, Pierre-Andre Piron Pierre-Andre PIRON [log in to unmask]