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Richard, I can't blame my sleeplessness on anti-depressants, because I don't take any, or eldepryl, either. I used to take eldepryl and that added to the problem. Currently I'm in the process of switching from regular sinemet (10/100's) to sinemet cr (25/100's). I take 8 a day, with 2 pramipexole 3 times a day and 5 baclafen (10 mg), a muscle relaxant for distonia, at bedime. My internist took pity on me and gave me a prescription for ambien (5 mgs.) which I've started taking. Last night 3/4 of a tablet enabled me to sleep uninterruptedly for 4-5 hours. I went back to sleep shortly and woke up around 4:30. That to me is a wonderful night's sleep and I feel gtreat today. Deo gratias! Merry Christmas! PAT