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Marti, Like you, I can't follow my neuro's instructions literally. I use them as a starting point and experiment a bit on my own. Right now I've taken three days off from work to adjust to sinemet CR, and I'm still fine tuning it. Here's my schedule so far: 5 AM: 1 CR and every two hours 15 minutes thereafter (he suggested three hours, but that's too long). This is my third day, and each day I've felt the need to take 3/4 tablet occasionally, as one was too much. Since I still work, I'm going to have to take part of a regular 10/100 to get started, as the CR takes almost an hour to kick in. The trick is to avoid overlapping and overmedication. Both evenings have been a problem, as the medicine doesn't work at all after dinner. I'm going out to dinner with friends tonight, and am undecided what to do. I'll try to bring most of the dinner home if I'm not too hungry. I'm seriously considering becoming a vegetarian, except that ALL food seems to be a problem, not just protein. I'm thinking about retiring soon, and after that may just adjust to my crazy schedule. Wednesday I was "off" all evening, but everything kicked in at bedtime, making me full of energy and ready to go, so I wrote the Christmas cards I had put off doing earlier in the evening. I guess this condition changes our lives in more ways than one! Good luck. Hope this helps. Pat Schark ([log in to unmask])