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WILLIAM ROMANOW <[log in to unmask]> wrote: "HAS ANYONE ELSE FELT THAT AN EXTRA AMOUNT OF PHYSCIAL ACTIVITY SEEMS TO USE YOUR DOSE OF SINEMET SOONER, OR THAT YOUR DOSE DOES NOT SEEM TO LAST AS LONG AS USUAL?????" I find this to be the case for both physical and mental activity that is prolonged. It seems logical to me. The neurotransitter - dopamine - is used to transmit a chemical message from one nerve cell to the next. If there is more activity; there are more messages; more dopamine will be used. Ron,59,dz PD 11 <[log in to unmask]> Ronald Vetter http://www1.ridgecrest.ca.us/~rfvetter/