Margaret, After being on Sinemet for the last 10 years with increasing dosages, I hit a condition where I experienced over medication and the dreaded dyskinesia or under medication with paralyzing bradykinesia. I have been ramping up on the Permax and decreasing the Sinemet over the last 3 weeks. The transition has been a terrible experience. I expect the process will take about three month before I am comfortable again. Check with your neurodoctor about Permax. Jon Stedman <[log in to unmask]> PS: What is the meaning of the "bid" and "tid" on prescriptions? It's not obvious to me...