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---------- Forwarded message ---------- Date: Sun, 31 Dec 1995 09:38:26 -0600 (CST) From: Steven E. Mayer <[log in to unmask]> To: [log in to unmask] > >>Margaret, >>After being on Sinemet for the last 10 years with increasing dosages, >>I hit a condition where I experienced over medication and the dreaded >>dyskinesia or under medication with paralyzing bradykinesia. >>I have been ramping up on the Permax and decreasing the Sinemet over the >>last 3 weeks. The transition has been a terrible experience. I expect the >>process will take about three month before I am comfortable again. >>Check with your neurodoctor about Permax. >> >>Jon Stedman <[log in to unmask]> >> >>PS: What is the meaning of the "bid" and "tid" on prescriptions? >> It's not obvious to me... >> >>REPLY from Steven Mayer [log in to unmask],; Dec29,1995 > I am a 66 year old retired research pharmacologist with dx of PD in >1992; moderate regression until, December, 1994, then increasing intractible >dyskinasia , especially of lower back and most leg muscles. Sinemet (9x >25/100 during day became less effective. I tried pergolide (Permax) last >March but quit because of sedation, poor relief of PD symptoms. Started >again abour 3 weeks ago with slowly increasing doses from 0.0.05 to 0.75 >mg/day in 3 divided administrations. Sinemet was reduced to 3x 25/100. This >time sedation and anxiety were not as bad. I do have longer "on" periods, >but can't count on more than a few hours in which to be productive. Most >terrible is "freezing" in public accompanied by intense urge for frequent >urination. > At this point I feel its worth continuing the Permax. > > "b.i.d." and "t.i.d." mean : twice a day and three times a day, >respectively. Good luck. > Steven >Steven E. Mayer, Ph.D. > > > Steven E. Mayer, Ph.D.