I recently posted a request from a friend who is having difficulty with her PD symptoms and also has had a fear of the medications..the following is from her...for the time, she wishes to remain anonomymous. I will foreward any responses to her...the information I have gathered here for her has been of much benefit, & has enabled her to take the first steps...Thank you!!!! Roberta My friend who I recently asked some questions for, wishes to express her warmest gratitude and heartfelt thanks to those who responded. She finally returned to her neurologist who started her on one Eldepryl per day two months ago, and, a week ago, one Amantadine (generic for Symmetrel) 100mg capsule once a day, soon to be increased to two. Although she notices some benefit such as steadier gait and less muscle stiffness and pain, as well as less slurring of speech, there are no other changes yet (too early? not high enough dose yet?) She was started on Amantadine as she is very susceptible to side effects of drugs and was told Amantadine was milder than Sinamet although that may be her next step. Anyone know the skinny? Have any of you tried Amantadine/Symmetrel? What were your experiences, doses, wearing-off time period? etc.? Her major side effect is generalized anxiety which can suddenly flip into anxiety attacks. She expects these to lessen as she becomes accustomed to the new med. Did any of you have any side effects? More importantly, were any of you started on this drug rather than Sinemet, and why? What do you think of it? Any input would be much appreciated. Also, she asks, how did you deal with the tremendous fear once "you" believed you had PD; the more positive input, the better (she's just coming out of denial). Thanks again.