Ben, my neuro calls my PD OFF DYSTONIA and refers to me as a YO=YO To explain better picture a continious series of UUUUU ...... ........ . . . . the dot on the left is where my meds loose effectiveness and ..... the dot on the right is where they begin to work again After a careful review of my med times it was determined that I was taking them near or at the bottom of this U The challenge was to smooth out the U to a shorter or not so deep bottom. We hoped that the liquidfying of my sinemet and the hourly "drink" would do it. IT HAS WORKED GREAT FOR ME FOR THE PAST 9 WEEKS My OFF's are very short lasting and not as deep as pre L>S> Speak with your neuro about L>S> it may not be for you. Keep us informed joyce [log in to unmask]