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Once again for each 25/100 Sinemet dilute into 100cc of OJ or TANG i.e 10 x 25/100 daily = 1000cc (almost on qt) of Liquid add 2 teaspoons of ASCORBIC ACID (POWERED VIT. C) divide the total number of dosage hours i.e. first pill at 6am last at 8pm = 15 hours divide 15 into total amount of liquid = hourly drink during severe off periods, you could divide the hourly drink into 2 and drink each 1/2 hr. PLEASE CONFER WITH YOUR NEURO BEFORE DOING THIS. Joyce [log in to unmask]