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I got a call this week telling me that Dr. Mark Corrigan of Upjohn reported that after testing pramipexole on 900 patients with PD and there was a 20 - 30% improvement in PD symptoms. Pramipexole is a more selective long lasting dopamine agonist. It is hoped that this drug will be more effective and have less longterm side effects than levadopa. Does anyone have first hand knowledge of this study? Cabergoline is another dopamine agonist being tested. It is a one dose per day agonist showing promise in patient trials. I hope one of these new drugs will prove out as Sinemet isn't proving to be the magic bullet - albeit Sinemet is the best drug we have for PD at this moment. BTW did any of the PD patients in these trials have RLS and find that their drug helped calm down the symptoms of RLS (restless leg syndrome)? RLs is a bigger pain to me than PD is? I mean PAIN literally as advanced RLS is very painful. Barbara Yacos <[log in to unmask]>