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Hi Margaret-- I have for the last several years noted (or my husbasand noted ) that changing my medication slightly seemed to "fool" my brain temporarily-- such as --if I have trouble now with liquid sinemet being effective and leaving me with too much" off" time -- I switch to mixing each tablet separately in 4oz. OJ and 4oz. for a while and then I can go back to the regular mixture. I don't understand a lot about my disease even though I have had PD for 18 years it still remains "mysterious" a lot of the time. I also have insomnia getting an average of 2 hrs. sleep per night. I usually seem to have a "storage of dopamine and am "On" sometimes up to 4 hrs.upon awakening. I don't understand why but it is always wecolme. Early morning (12 am - 4 am) are usually my best time and most productive (mentally and physically REGARDS FROM PITTSBURGH.