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In my youth, I smoked both cigarettes and a pipe from time to time. I used to smoke because I enjoyed it but always found it very easy to stop and couldn't understand how people became addicted. Is it possible that people who are going to develop PD have a brain chemistry that does not respond to nicotine? This might explain why non smokers are more likely to get PD. Have Parkies on this list found giving up smoking difficult? Nigel Cockle (PD 12 years)